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KMID : 0358319800210010008
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Korean Journal of Urology
1980 Volume.21 No. 1 p.8 ~ p.17
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Amiloride Action on Oxamide Treated Kidneys and lnfluence of Oxamide on the Distribution of lntrarenal Blood Flow
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조강선/Cho KS
민병갑/최봉규/국영종/Min BK/Choi BK/Kook YJ
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Abstract
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"In an attempt to obtain evidence in the mechanism of stone formation, the effectiveness of Amiloride. a K-sparing diuretic known to act on the distal nephron. on the kidney with oxamide-induced urolithiasis was investigated. Futhermore. the influence of stone formation on the distribution of intrarenal blood flow and the effect of Amiloride on them were also studied. Most prominent derangements of renal function observed during stone formation were decreases of both C_ PAH and Ccr indicating the curtailment in renal hemodynamics. The
oxamide-treated kidney also responded to Amiloride with typical natriuresis and antikaluresis. in the same fashion with normal kidneys. The experiments in which the intrarenal blood flow distribution was measured by PAH-extraction technique raveled that mainly the cortical blood flow was curtailed, whereas non-cortical blood flow (medullary flow) did not change during oxamide-stone formation. Amiloride did not influence the intrarenal b100d flow distribution both in normal and oxamide kidneys. These observations suggest that oxamide-stone formation was initiated not by tubular necrosis produced by the toxic action of oxalate on the tubules, but rather by mechanical obstruction of the tubules."
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